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Vaccine Science is Not Settled
   
       
       
       
 

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Don't fight the system.
Go in the system and take them down on their own faults.

Alle acties komend uit wraak of ego zullen mislukken.
Alleen acties vanuit een hart en ziel zullen slagen.

In deze blog geef ik mijn zienswijze van de huidige wereld weer. 
Ik beroep me op het recht die geldt vanuit het Universum, namelijk: Het recht van respect naar elke energievorm in het Universum. In de menselijke wetten is het omschreven in het UVRM als zijnde: Artikel 1 Alle mensen worden vrij en gelijk in waardigheid en rechten geboren. Zij zijn begiftigd met verstand en geweten, en behoren
zich jegens elkander in een geest van broederschap te gedragen. In de reeds niet meer geldende Nederlandse grondwet staat het beschreven als zijnde: Artikel 1 Allen die zich in Nederland bevinden, worden in gelijke gevallen gelijk behandeld. Discriminatie wegens godsdienst, levensovertuiging, politieke gezindheid,
ras, geslacht of op welke grond dan ook, is niet toegestaan.
   
       
 
 
   
       
 

 

Vaccine Science is Not Settled: A Critical Review of the Literature

Purpose

Since the modern inception of public mistrust in vaccines in the late 1990s, in the wake of a since-retracted study published in The Lancet by Andrew Wakefield in 1998,[1] a handful of sporadic and hastily completed epidemiological studies have been used by the media and various government agencies as evidence that vaccines are safe. As Mark Twain quipped, “Facts are stubborn, but statistics are more pliable.” There are many ways in which data is chosen, manipulated, and compared, and the average person with only a basic knowledge of statistical methods must take the word of the author that the results are “proof.” Important policy decisions and laws are being made, and public debate is being suppressed, based on the unexamined assumption that the science on vaccine safety has been settled. The Alliance for Natural Health USA (ANH-USA) and Dr. Brian Hooker have teamed up to rigorously scrutinize twelve of the papers most often cited as proof positive that vaccines are safe. Each review presents the study’s overview and findings, along with an analysis of the findings, and a final statement of the authors’ conflicts of interest.

Summary of Findings

Generally speaking, each study was conducted by researchers connected to government immunization offices or drug companies, thereby giving them a vested interest to “prove” that vaccines are universally safe. Other problems were identified: poor sample choice, data inconsistencies, unproven assumptions, subjective dismissals of data contrary to conclusions, faulty comparisons, unreliable methods, and unsupported conclusions. Given these flaws, one cannot take this research as proof positive that vaccines are as universally safe for children as pharmaceutical companies and government agencies claim. We do not posit that vaccines are a cause of autism—but we point out that these studies cannot allay all concerns, given the following issues.
No evidence for measles, mumps, and rubella vaccine-associated inflammatory bowel disease or autism in a 14-year prospective study (1998)[2]
Authors: Peltola H, Patja A, Leinikki P, Valle M, Davidkin I, Paunio M.

Study overview: This study was conducted in response to a previous study conducted by Andrew Wakefield et al. in 1998 which suggested a link between the measles, mumps, and rubella vaccine, and chronic inflammatory bowel disease related to autism.[3] Peltola et al. reviewed data from the US Vaccine Adverse Event Reporting System (VAERS) to claim that GI symptoms were rare after the measles, mumps, and rubella (MMR) vaccine. Their findings come from data that showed 31 individuals complaining of gastrointestinal symptoms after receiving the MMR vaccine out of 3 million vaccines administered in the years studied. This study is often cited as evidence that the MMR vaccine is safe.

Study’s flaws: The VAERS database is a federally funded surveillance system based on self-reporting, meaning that only those with the wherewithal to report their adverse event will do so.[4] The VAERS system itself states: “‘Underreporting’ is one of the main limitations of passive surveillance systems, including VAERS. The term ‘underreporting’ refers to the fact that VAERS receives reports for only a small fraction of actual adverse events.”[5] By VAERS’ own accounts, many more than 31 may have experienced symptoms without reporting them. This type of study is inherently limited by relying solely on VAERS data. It cannot rule out that a larger population experienced GI systems after receiving the vaccine, nor can it rule out that a specific subpopulation could be vulnerable to the MMR vaccine, similar to the children evaluated in the 1998 Lancet study.

Conflicts of interest: This study was funded by Merck, which makes the current formulation (MMR-II) of the measles, mumps, and rubella vaccine, and stands to profit from results that disprove any dangers.

A population-based study of measles, mumps, and rubella vaccination and autism (2002)[6]
Authors: Madsen KM, Hviid A., Vestergaard M., Schendel D, Wohlfahrt J, Thorsen, P.

Study overview: Admitting that previous studies disproving the link between MMR vaccine and autism were limited by design, and responding to the World Health Organization’s call for further study, the authors sought a larger data sample to increase the statistical analysis capabilities. They conducted a retrospective study on children born in Denmark between 1991 and 1998, after the MMR vaccine was approved for use in Denmark in 1987. They compared the cohort of unvaccinated children to the nearly half a million children who received the vaccine, and found an insignificant relative risk of autism and autism spectrum disorders in the vaccinated population.

Study’s flaws: The data presented by the researchers in their findings is inconsistent, calling into question their entire methodology. Table 1 reports 269 vaccinated children with autistic disorder and 47 unvaccinated children with autistic disorder. Table 2 reports 263 vaccinated children with autistic disorder and 53 unvaccinated children with autistic disorder. Using one set of numbers instead of the other changes the results from slightly less than a relative risk of 1 to slightly more, when the vaccinated cohort is compared to the unvaccinated. That their findings are based on inconsistent data should be enough for credible reporting on vaccinations to not cite the study. Also, the authors themselves admit that this type of study does not rule out that a subpopulation could be vulnerable to the MMR vaccine as presented in the 1998 Lancet study.

Conflicts of interest: This study was funded by the National Immunization Program (NIP) at the US Centers for Disease Control and Prevention (CDC), which had a vested financial interest in increased uptake of the MMR vaccine, as it directly bought the vaccine from Merck and distributed it for reimbursement to the states’ public health departments. Also, one of the co-authors of the study, Dr. Diana Schendel, was a CDC employee at the time of publication. In addition, three of the co-authors (Dr. Mads Melbye, Mr. Jan Wohlfahrt, and Mr. Anders Hviid) were employees of Staten Serum Institut, a for-profit company that manufactures and distributes vaccines in Denmark.

Do children who become autistic consult more often after MMR vaccination? (2001)[7]
Authors: DeWilde S, Carey IM, Richards N, Hilton SR, Cook DG

Study overview: The researchers posited that if the MMR vaccine was causing autism, then children with symptoms would have a significant increase in general practitioner doctor visits post-immunization. Data from England during the years 1989–2000 was used to compare visits to the primary care provider of autistic children versus visits by non-autistic children within six months of receiving the MMR vaccine. They found no significant increase in doctor visits within this six-month time period.

Study’s flaws: The premise of this paper is based on the assumption that if the MMR causes autism, then the number of general practitioner visits would increase for autistic children after the administration of their first MMR vaccine. This does not take into account the total number of practitioner visits, which would include specialist visits. It stands to reason that most general practitioners would not see autistic children at a greater frequency but instead would make referrals to specialists, such as behaviorists, neurologists and gastroenterologists, who would be sought out to attend to the symptoms of an adverse reaction. The data also does not show how many children may have sought treatment for their symptoms outside of the narrow 6-month window studied. Finally, there were no autism specialists among the authors who could speak to how and when autism presents and is diagnosed.

Conflicts of interest: DG Cook, one of the paper’s authors, worked as a professor in the Department of Public Health Sciences at St. George’s Hospital Medical School. Public health practitioners are generally trained to accept vaccination policies without question and would not serve as objective researchers.

Measles, mumps, and rubella vaccination and bowel problems or developmental regression in children with autism: population study (2002)[8]
Authors: Taylor B, Miller E, Lingam R, Andrews N, Simmons A, Stowe J.

Study overview: This paper focused on autism cases identified in five districts of London, England, for children born nine years prior to and nine years after the introduction of the MMR vaccine in the UK in 1988. The authors hypothesized that if autism were related to the MMR vaccine, then there would be a corresponding increase in the number of autism cases after 1988 as well as rising rates of regressive autism (in which a child with typical developmental levels suddenly begins to lose speech and social skills and is subsequently diagnosed with autism). Additionally, the researchers sought to determine if the MMR vaccine was linked to increased incidence of bowel disorders among children with autism, perhaps indicating a “new variant” form of autism. The authors concluded that there was no “new variant” form of autism characterized by regressive autism and bowel disorders, and further, that there was no link between the MMR vaccine and autism.

Study’s flaws: The authors claim that there is no statistical evidence of any link between the MMR vaccine and autism, yet the raw data suggests otherwise. Consider their report of the number of children whose parents reported symptoms: only 29% of parents reported an incidence of autism, regressive autism, or bowel disorder before the child was vaccinated, as opposed to 58% of parents who reported symptoms after the vaccine. Only 13% of reported cases occurred in unvaccinated children. The authors caution in their conclusion that some parents may have changed the age at which they noticed symptoms after the Wakefield study made news, but this is complete conjecture on their part, and certainly does not explain such a large differential. Their own data suggests that more children overall were “regressing” after the MMR vaccine rather than before.

Conflicts of interest: Two of the study’s authors, Nick Andrews and Elizabeth Miller, are a part of the UK’s immunization division in the Public Health Laboratory Service, Communicable Disease Surveillance Center. This particular division is in charge of immunization uptake in the UK as well as vaccine safety.

No evidence for a new variant of measles-mumps-rubella-induced autism (2001)[9]
Authors: Fombonne E, Chakrabarti S.

Study overview: This study sought evidence of a new form of autism characterized by developmental regression (in which children who seemed to be achieving developmental milestones began losing ground and were subsequently diagnosed with some form of autism) and bowel disorders in children, as posited by the Wakefield study. The authors contended that if such a new form existed, then they should find statistical evidence in at least one of the following ways:

there should be a higher incidence of this type of disorder in the general population;
first parental concern should be closer to mean vaccination age in vaccinated vs. unvaccinated children;
there should be an increase in regression of autistic children in vaccinated vs. unvaccinated children;
autistic children with regression would be clustered around age at vaccination;
autistic children with regression would have distinct symptoms with similar severity; or
regression autism would be associated with gastrointestinal and/or bowel disorders.
The authors used three sample sets to identify statistical relationships between the administration of the MMR vaccine and evidence of any of the above listed indicators. The first sample was a purposive sample comprised of children who had been identified with pervasive developmental disorders through a UK survey in Staffordshire. The sample consisted of 96 children who were born between 1992 and 1995, all but one of whom had received the MMR vaccine. The second sample was a convenience sample, in which the subjects volunteered or were chosen to take part in the study, specifically culled from the practice of the paper’s first author, Dr. Eric Fombonne. This sample was also comprised of children who received the MMR vaccine after 1988 (when the MMR vaccine was introduced), including 68 children born between 1987 and 1996 who had a confirmed diagnosis of Pervasive Developmental Disorder (PDD). The third sample was also a convenience sample, of 99 individuals with autism who were born before the introduction of the MMR vaccine.

The authors claim that their analysis found no statistical evidence to support any of the above claims, thereby establishing there was no new form of autism and no link to the MMR vaccine.

Study’s flaws: Comparing purposive samples to convenience samples is not a valid research method and therefore should not be relied upon to make inferences regarding the MMR vaccine and autism. The authors also do not list the source of the third convenience study, further calling into question the validity of the sample.

Conflicts of interest: After this paper was published, lead author Dr. Fombonne violated scientific ethics at his post at Montreal Children’s Hospital and McGill University when he improperly used samples derived from autistic children for another study unauthorized by their parents. Dr. Fombonne has also testified as an expert witness for vaccine manufacturers and against families with reportedly vaccine-injured children, both in civil courts and the National Vaccine Injury Compensation Program for the US.

Time trends in autism and in MMR immunization coverage in California (2001)[10]
Authors: Dales L, Hammer SJ, Smith NJ

Study overview: The goal of the study was to find a correlation between increased autism rates and increased MMR vaccination rates in the general population. The authors used an ecological study, which looks at the whole population for incidences of a disease rather than examining individual cases of autism. The data came from the state of California between 1980 and 1994, using kindergarten enrollment to determine the number of children vaccinated between 17 and 24 months of age, and comparing it to the number of children born during these years who received services from the California Department of Developmental Services after an autism diagnosis. Their analysis shows that while autism rates in California increased in this time period by 373% (from 44 cases per 100,000 live births to 208 cases per 100,000 live births), the relative uptake of the MMR vaccine by 24 months increased by only 14%, leading to their claim that the rise in autism rates cannot be account for by the relative rise in MMR vaccinations.

Study’s flaws: A relationship between the MMR vaccine and autism cannot be ruled out at an individual level based on this comparison of overall rates alone. Increases in the use of the developmental centers may be bolstered, as the authors acknowledged, by increased availability of the centers and increased public awareness of autism. Further, in a rebuttal, Edwards and Baltzan remapped the data and found that the age at immunization was actually trending younger than 17 months between 1981 and 1993,[11] and that the original comparison plots were vertically compressed—and once adjusted actually suggest a correlation, if not a causation.

Conflicts of interest: The lead author of this publication, Dr. Loring Dales, was the head of the immunization branch of the California Department of Health Services at the time of publication of this paper. Dr. Dales then had a responsibility to maintain vaccine uptake (including the MMR vaccine) in the state of California.

Mumps, measles, and rubella vaccine and the incidence of autism recorded by general practitioners: a time trend analysis (2001)[12]
Authors: Kaye JA, del Mar Melero-Montes M, Jick H.

Study’s overview: This study was a time trend analysis, where researchers look to see if one variable increases or decreases in tandem with another factor over a period of time. The researchers looked at the rate of increase of autism diagnoses among children between 1988 and 1999, and then specifically looked at boys born between 1988 and 1993, and the rate of MMR vaccine administration (uptake) during the same time periods. The authors claimed that there was no correlation despite a marked increase in autism incidence with time, because trends in MMR uptake remained unchanged.

Study flaws: Instead of defining autism incidence based on when the child was born, the study authors instead defined autism incidence based on diagnosis rate during diagnosis year, with the denominator corrected for age of diagnosis. This method gives a bias towards autism diagnosed at younger ages and is not a true measure of autism incidence. Therefore, this section of the analysis is essentially meaningless in determining true autism incidence versus MMR uptake. The rate of MMR uptake remained steady at over 95% throughout the birth cohorts while the autism incidence (as measured by the researchers) increased sevenfold. MMR uptake could not possibly proportionally increase as it was already a high 95%, so this type of temporal study sheds no light—it was de facto “proof” by design.

Conflicts of interest: The authors of this paper were residents at the Boston Collaborative Drug Surveillance Program at Boston University School of Medicine. This program is supported in part by grants from AstraZeneca, Berlex Laboratories, Boehringer Ingelheim Pharmaceuticals, Boots Healthcare International, Bristol-Myers Squibb Pharmaceutical Research Institute, GlaxoSmithKline, Hoffmann-La Roche, Janssen Pharmaceutica Products, RW Johnson Pharmaceutical Research Institute, McNeil Consumer Products, and Novartis Farmaceutica. Funding for their residency program is directly tied to those profiting from the vaccine companies their claims protect.

MMR and autism: further evidence against a causal association (2001)[13]
Authors: Farrington CP, Miller E, Taylor B.

Study overview: The authors of this study investigated time trends of autism diagnoses in a case series involving 357 UK children diagnosed with autism. They looked at temporal relationships, that is, how much time elapsed between administration of the MMR vaccine and a subsequent autism diagnosis. Farrington et al. looked at two different time spans—36 months and 60 months, respectively—between the MMR vaccine and the first reported parental concern, as a previous study had only looked for a closer temporal relationship. Additionally they looked at 24 months as an interval between the MMR vaccine and onset of regressive autism. They claim their results showed no correlation as the incidence of autism increased while the MMR uptake remained steady. Importantly, the World Health Organization has used these findings to support their immunization policy.[14]

Study’s flaws: Despite the authors’ claims, the data presented as evidence in the paper instead seems to actually confirm a temporal relationship between the MMR vaccine and the age of first diagnosis. This is best shown using their own data charts. Figure 1 includes the age of first diagnosis for 64 unvaccinated children with autism and shows significantly more “scatter,” as compared to Figure 2, for 231 children receiving a single dose of the MMR vaccine, where diagnoses tend to cluster between 0 and 30 months post-vaccination.

Fig. 1. Distribution of age at autism diagnosis (in months) of 64 unvaccinated children with autism.

Vaccine1

Fig. 2. Distribution of (top) age at autism diagnosis and (bottom) age at vaccination (in months), of 231 children with autism who received a single dose of MMR vaccine.

Vaccine2

Figure 3, of 62 children receiving two doses of the MMR vaccine, also shows clustering between 0 and 30 months after administration of the first vaccine.

Vaccine3

Fig. 3. Distribution of (top) age at autism diagnosis and (bottom) ages at vaccination (in months) of 62 children with autism who received two doses of MMR vaccine.

The study authors blame this phenomenon on time trends where cases post-MMR vaccine tend to be newer and cases without the MMR vaccine tend to be older, because newer cases would be subject to earlier diagnosis and screening. This statement is completely unsubstantiated in the paper, however, and does little to counter the clear clustering of autism diagnoses after vaccination.

Conflicts of interest: One of the authors, Dr. Elizabeth Miller, was a chief official at the Immunization Division of the UK’s Public Health Laboratory Service (PHLS) and possessed an institutional conflict of interest, given the PHLS’s stake in maintaining high vaccination rates in the UK.

Autism and measles, mumps, and rubella vaccine: no epidemiological evidence for a causal association (1999)[15]
Authors: Taylor B, Miller E, Farrington CP, et al.

Study overview: This study provided a comparison of autism rates before and after the introduction of the MMR vaccine in the UK in 1988. Data showed a sharp increase in autism incidence in the early 1990s but did not appear to correlate with MMR vaccine uptake, which plateaued soon after introduction. According to the study authors, although most evidence did not show a temporal relationship between MMR vaccine timing and “autism onset,” there is compelling data for the age of first parental concern clustering between 0 and 6 months of administration of the MMR. The authors dismiss this finding by arguing that parents chose an age of first concern of 18 months simply because it was a round number.

Study’s flaws: The claim that parents chose an age of concern of 18 months because it was a “round number” is unsubstantiated and therefore not a valid explanation for the cluster of data that shows otherwise. Data findings should not be subjectively dismissed at the convenience of the researchers.

Conflicts of interest: Two of the study authors (Dr. Elizabeth Miller and Ms. Pauline Waight) are from the UK’s Immunisation Division, Public Health Laboratory Service Communicable Disease Surveillance Centre, which reflects institutional conflict of interest as this particular agency is responsible for increasing vaccine uptake within the UK population.

Neurologic disorders after measles, mumps, rubella vaccination (2002) [16]
Authors: Makela A, Nuorti JP, Peltola H.

Study overview: This study used hospital records to determine if there was a relationship between when the MMR vaccination and hospitalizations of children for three different diagnoses: encephalitis (within three months of MMR vaccine); aseptic meningitis (within three months of vaccination); and autism (throughout time period of analysis, which was 1982–86). Data was taken from hospital records in Finland. The authors claim that no temporal relationship exists between the MMR vaccine and any of the three diagnoses, including autism in a hospital setting. They report there was no clustering of hospitalizations for autism at any intervals following immunization.

Study’s flaws: This study actually clearly shows that peak rates of autism diagnoses occurred after the MMR vaccine was administered, especially in the 0 to 6 month window following vaccination. Additionally, the data is based on autism “hospitalization” visits, which is likely an under-ascertainment of actual autism cases, given that many cases are diagnosed in an outpatient setting.[17] Also, diagnoses in a hospital setting do not reflect the actual onset of symptoms, including regression, and the authors of this paper directly admit that this is a flaw in their analysis.

Conflicts of interest: Major MMR and MMR-II manufacturer Merck funded this study, and held a worldwide monopoly on these vaccines during the time of the research.

Pervasive developmental disorders in Montreal, Quebec, Canada: prevalence and links with immunizations (2006)[18]
Authors: Fombonne E, Zakarian R, Bennett A, Meng L, McLean-Heywood D.

Study overview: This study focused on ecological methods—looking at the whole population for incidences of a disease rather than examining individual cases of autism—based on a population of students in a large school district in Montreal, Canada. The authors looked at the increases in developmental disorders which were identified in children by schools’ special needs teams, and compared them to (a) estimates of exposure to thimerosal (ethylmercury), which was phased out during the study, over the same time period, and (b) to changes in the MMR vaccination trends, including a switch to a two-dose MMR schedule during the study period. The authors concluded that there was no relationship between thimerosal exposure and increased developmental disorders. Further, they claimed that while the vaccination rate experienced a dip during the study period, there was no corresponding decrease in developmental disorders and also that there was no change in developmental disorders associated with the subsequent increase to a two-dose schedule.

Study’s flaws: The school district represented in this study accounts for only 14% of the total school population in Montreal but has the highest rates of pervasive developmental disorder (PDD, aka autism) diagnosis in the five total districts, and in some cases PDD rates were three times higher within this district. Also, the claim that the thimerosal exposure in the Canadian vaccine schedule starting in 1996 was “nil” is false. At this point in time, the thimerosal free HepB formulation had not yet been introduced (not until 2001) and the thimerosal containing “Penta” vaccine was administered, leading to a cumulative maximum dosage of 137.5 micrograms mercury. Essentially, this fact, along with the lack of actual vaccine records for cohort members, renders any time trend comparison between autism/ASD/PDD prevalence and thimerosal exposure useless.

Also, regarding the MMR vaccine uptake, the study authors use uptake as a metric of vaccine coverage, which was not done for the thimerosal analysis. The authors do not accurately reflect the effect of the introduction of two doses of the vaccine in 1996, which would essentially double the viral load administered to each individual. Finally, the errors associated with autism/ASD/PDD diagnoses essentially obviate any true indication of an upward trend, given that there is significant overlap in the 95% CI range at each year reported, including the endpoints of 1987 and 1998.

Conflicts of Interest: The lead author of this study, Dr. Eric Fombonne, has significant conflicts of interest, as he has many times represented vaccine manufacturers as an expert witness in thimerosal litigation, opposing the families of vaccine injured children.

Age at first measles-mumps-rubella vaccination in children with autism and school-matched control subjects: a population-based study in metropolitan Atlanta (2004)
Authors: DeStefano F, Bhasin TK, Thompson WW, Yeargin-Allsopp M, Boyle C.

Study’s overview: The authors were looking for an association between the increased rates of autism in children and the MMR vaccine, both among the general population and in sub-groups of children. Researchers compared the vaccination schedules of autistic children from the general population to a control group of school-matched children who did not have autism. This study focused on children enrolled in public school within five districts in metropolitan Atlanta who received their first MMR vaccine at different time intervals. Autism cases were matched with three controls based on gender, birth year, and school of enrollment for a total sample of 2448 individuals. The researchers concluded that similar proportions of case children (those with autism) and control children (school-matched subjects) were vaccinated according to the recommended schedule and likewise with any of the subgroups also studied. One sub-group, boys ages 3 to 5 enrolled in special education services, had a rate of immunization earlier than their school-matched controls. However, the authors argue that this subgroup would have had the earlier immunization as a requirement for receiving school-based services and thus dismiss it as insignificant.

Study’s flaws: The study actually showed statistically significant relationships between autism incidence and MMR timing for all individuals considered in the study (OR: 1.49, 95% CI: 1.04–2.14) with a stronger association for males only (OR: 1.67, 95% CI: 1:10–2.53) for those individuals who received their first MMR vaccine prior to 36 months of age, with a reference of those individuals who received their MMR vaccine after 36 months of age. This is quite a compelling relationship, though the authors dismiss the effect, stating that children with autism would be enrolled in special education services which would require earlier vaccination with the MMR. This statement makes no sense, in light of the fact that the relationship is observed to come exclusively from boys in the cohort and not girls (no statistically significant relationship is seen when considering girls separately). There is no reason to assume that boys enrolled in special education services would receive earlier MMR vaccines than girls enrolled in the same programs.

Conflicts of interest: Two of these individuals were employees of the National Immunization Program of the US Centers for Disease Control and Prevention (CDC), which is charged to increase immunization rates in the US in order to prevent outbreaks of infectious diseases. Thus there was a propensity against finding a causal relationship between vaccines and vaccine adverse events, which is demonstrated clearly in the text of the paper by the authors’ faulty explanation when statistically significant relationships are observed. Dr. William Thompson, co-author of the paper and lead statistician with the CDC, has recently (August 2014) come forth with evidence of fraud committed specifically regarding this paper, and has launched a complaint against his co-authors regarding both the outcomes and the interpretations of the results of this study.

Conclusion
Studies undertaken by researchers with a vested interest either in immunization uptake or vaccine manufacture should be subjected to greater scrutiny. While the goal should always be the eradication of disease, both the profit motive and bureaucracy impede the necessary safeguards to public health. While the majority of a population may suffer no ill effects from vaccines, subgroups of the population may be at risk. After the public started questioning the safety of vaccines in the late nineties, public health agencies and drug manufacturers were quick to produce more than a dozen studies “proving” the safety of vaccines. Applying scientific scrutiny to some of these studies shows that they do not, beyond dispute, prove that vaccines are safe. Further independent, open-minded study is needed to prove the safety of vaccines for all subgroups of the population.

[1] Wakefield AJ, Murch SH, Anthony A, et al. Ileal-lymphoid-nodular hyperplasia, non-specific colitis, and pervasive developmental disorder in children. Lancet 1998; 351: 637 41.

Dr. Wakefield, together with twelve other colleagues, published a paper in the famed British journal The Lancet—a case study of twelve young patients who presented with a new type of bowel disorder, all of whom had autism and developmental delays. Parents reported that each of these children regressed into their condition after receiving the MMR vaccine (for measles, mumps, and rubella). It is important to note that this paper neither confirmed nor denied a connection between regressive autism and the MMR vaccine. However, it did indicate that it was an area worthy of further study.

[2] Peltola H, Patja A, Leinikki P, Valle M, Davidkin I, Paunio M. No evidence for measles, mumps, and rubella vaccine–associated inflammatory bowel disease or autism in a 14-year prospective study. Lancet 1998; 351:1327–8.

[3] Wakefield AJ, Murch SH, Anthony A, et al. Ileal-lymphoid-nodular hyperplasia, non-specific colitis, and pervasive developmental disorder in children. Lancet 1998; 351: 637 41.

[4] https://vaers.hhs.gov/data/index

[5] Ibid.

[6] Madsen KM, Hviid A, Vestergaard M, et al. A population-based study of measles, mumps, and rubella vaccination and autism. N Engl J Med 2002; 347:1477–82.

[7] DeWilde S, Carey IM, Richards N, Hilton SR, Cook DG. Do children who become autistic consult more often after MMR vaccination? Br J Gen Pract 2001; 51:226–7.

[8] Taylor B, Miller E, Lingam R, Andrews N, Simmons A, Stowe J. Measles, mumps, and rubella vaccination and bowel problems or developmental regression in children with autism: population study. BMJ 2002; 324: 393–6.

[9] Fombonne E, Chakrabarti S. No evidence for a new variant of measles, mumps, rubella–induced autism. Pediatrics 2001; 108:e58.

[10] Dales L, Hammer SJ, Smith NJ. Time trends in autism and in MMR immunization coverage in California. JAMA 2001; 285:1183–5.

[11] Michael Edwardes, PhD; Marc Baltzan, MD, FRCPC. MMR Immunization and Autism. JAMA June 13, 2001. http://jama.jamanetwork.com/issue.aspx?journalid=67&issueid=4787

[12] Kaye JA, del Mar Melero-Montes M, Jick H. Mumps, measles, and rubella vaccine and the incidence of autism recorded by general practitioners: a time trend analysis. BMJ 2001; 322:460–3.

[13] Farrington CP, Miller E, Taylor B. MMR and autism: further evidence against a causal association. Vaccine 2001; 19:3632–5.

[14] http://apps.who.int/iris/bitstream/10665/107553/1/e82636.pdf.

[15] Taylor B, Miller E, Farrington CP, et al. Autism and measles, mumps, and rubella vaccine: no epidemiological evidence for a causal association. Lancet 1999; 353:2026–9.

[16] Makela A, Nuorti JP, Peltola H. Neurologic disorders after measles, mumps, rubella vaccination. Pediatrics 2002; 110:957–63.

[17] Madsen K, Lauritsen M,Pedersen C, Thorsen P, Plesner A, Andersen P, Mortensen P. Thimerosal and occurrence of autism: negative ecological evidence from Danish population-based data. Pediatrics 2003; 112:604-606.

[18] Fombonne E, Zakarian R, Bennett A, Meng L, McLean-Heywood D. Pervasive developmental disorders in Montreal, Quebec, Canada: prevalence and links with immunizations. Pediatrics 2006; 118:e139–50.

http://www.anh-usa.org/vaccine-science-is-not-settled-a-critical-review-of-the-literature/

 

 

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Title: Verboden Publicaties
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